NYC mpox cases increase again in September, surpassing 2025 monthly high
October 9, 2025
New York City’s recent rise in mpox cases signals a concerning return of the virus, particularly among men who have sex with men. September’s 61 cases mark the highest monthly total of 2025, underscoring the city’s ongoing vulnerability despite previous containment efforts. Public health officials attribute the uptick to seasonal trends, yet the persistence of double-digit weekly case counts highlights the need for sustained vaccination, testing, and education. The availability of free Jynneos vaccines across 13 city sites is crucial, but renewed community engagement remains essential to prevent complacency and protect vulnerable populations from another widespread outbreak.
New York City’s mpox resurgence serves as a sobering reminder that the virus has not disappeared, even after the city’s successful 2023 declaration marking the end of its major outbreak. September’s 61 confirmed cases represent the highest monthly total so far this year, and the trend shows no sign of slowing. The following week brought another record, with 19 new cases reported, pushing mpox back into public focus after months of steady but quiet transmission.
The virus continues to disproportionately affect men who have sex with men, accounting for nearly all reported infections. Manhattan and Brooklyn remain the most affected boroughs, while Staten Island reported no cases in September. Health officials describe the pattern as a “seasonal trend,” consistent with increased social gatherings during spring and summer. Yet the sustained transmission into the fall suggests that behavioral factors, vaccination gaps, and possible waning immunity may all be contributing.
The Jynneos vaccine remains the cornerstone of prevention. Administered in two doses 28 days apart, it significantly reduces infection risk and severity. The city recommends vaccination for men, trans, non-binary, and gender-nonconforming individuals who may be exposed through intimate contact, as well as travelers to areas where clade I mpox is spreading. The New York City Health Department continues to offer free vaccinations at six sexual health clinics across the five boroughs, ensuring access even for uninsured individuals.
Public health success will depend not only on vaccine availability but also on rebuilding trust and awareness within the LGBTQ+ community. Continued outreach, education, and stigma-free dialogue remain essential to preventing future spikes. Mpox may no longer dominate headlines, but New York’s recent surge proves that vigilance, vaccination, and open communication are still vital to protecting community health.