Increase in Mpox cases reported in Baltimore, though risk to public remains low
December 1, 2025
Baltimore health officials have reported a rise in Mpox cases, with 24 confirmed infections so far this year, more than half occurring since September. Although the overall risk to the public remains low, the trend underscores the need for vigilance among higher-risk groups such as gay and bisexual men and those with multiple sexual partners. Clade II, the milder strain, continues to circulate in the U.S., while no cases of the more severe Clade I have been identified locally. Health authorities are urging eligible residents to get vaccinated through city clinics and primary care providers to prevent further transmission.
Baltimore has seen a notable increase in Mpox cases in 2025, marking a shift after two years of relatively low transmission. City health officials reported 24 confirmed infections between January and November, more than half of which occurred since September. While this number is significantly lower than the 241 cases recorded during the 2022 global outbreak, the upward trend prompted a renewed public advisory.
Health Commissioner Dr. Michelle Taylor emphasized that the overall risk to the general public remains low but urged caution for those at greater risk, including gay and bisexual men and people with multiple sexual partners. Mpox spreads through close physical contact, including sexual activity and shared household items. The infection typically causes a painful rash, lesions, fever, swollen lymph nodes, and fatigue, lasting two to four weeks. Most people recover without serious complications, but immunocompromised individuals face higher risks.
The virus exists in two clades: Clade II, responsible for milder cases, has persisted at low levels in the U.S. since 2022. Clade I, the more severe strain, was recently detected in California without a travel link for the first time, raising concerns about possible domestic spread. No Clade I cases have been reported in Baltimore or Maryland.
Since the 2022 outbreak began, Maryland has reported 857 cases and three deaths, with Baltimore City and Prince George’s County accounting for most infections. Over 12,900 Marylanders have been vaccinated against Mpox.
Health officials continue to encourage vaccination through Baltimore’s Sexual Health and Wellness clinics and primary care providers. Public awareness, early symptom recognition, and vaccination remain the strongest tools for preventing another surge. Though Baltimore’s numbers are far below historic peaks, the resurgence serves as a reminder that vigilance and prevention efforts must continue to protect vulnerable populations.