Chicago sees rise in mpox cases in recent months, health officials say
September 22, 2025
Chicago is experiencing a sharp increase in mpox cases, with 67 infections reported since late June compared to just 11 in the previous three months. Health officials warn that the virus, known for its painful rash and flu-like symptoms, poses greater risks for immunocompromised individuals and those with underlying health conditions. The Chicago Department of Public Health urges residents at higher risk to complete the two-dose vaccination series, the strongest available protection. With transmission occurring through close contact, shared materials, or respiratory droplets, the city’s rising case numbers underscore the urgent need for vigilance, vaccination, and community responsibility.
Chicago health officials are sounding the alarm after a significant rise in mpox cases over the past three months. From late June through September, the city recorded 67 infections, compared to only 11 cases and one hospitalization between April and June. This trend marks a concerning shift, especially as mpox continues to cause painful rashes, flu-like symptoms, and, in some cases, severe illness requiring hospitalization. Individuals with compromised immune systems or other underlying health conditions are particularly vulnerable.
The Chicago Department of Public Health has urged residents, particularly those considered at higher risk, to prioritize vaccination. Completing the recommended two-dose series provides the strongest protection against the virus, not only reducing the risk of infection but also lessening severity if illness occurs. Despite the availability of vaccines, uptake has lagged nationally, leaving many people without full protection at a time when vigilance is crucial.
Mpox spreads primarily through close physical contact, including exposure to body fluids or sores, sharing bedding or clothing, and respiratory droplets through kissing, coughing, or sneezing. These routes of transmission mean that prevention relies not only on vaccination but also on community awareness and responsibility. Encouraging safe practices, recognizing early symptoms, and reducing stigma surrounding the disease are essential to controlling its spread.
Chicago’s recent spike serves as a reminder that mpox has not disappeared. Though global attention has shifted elsewhere, the virus continues to circulate and can resurface quickly if prevention measures lapse. With higher numbers now evident in the city, local officials emphasize that public cooperation and vaccine completion are key tools in protecting both individuals and communities. The resurgence of mpox highlights the need for proactive public health action and shared responsibility to prevent wider outbreaks.