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Case study: Mpox in nursing home worker resulted in no spread

February 5, 2025

A new study in the American Journal of Infection Control highlights the effectiveness of standard infection control measures in preventing mpox transmission in healthcare settings. In 2023, a Kentucky nursing home worker with mpox exposed up to 56 residents while providing direct care, yet no secondary infections occurred. The facility implemented post-exposure prophylaxis (PEP) with Jynneos vaccine for nearly half of the residents, but researchers suggest that adherence to standard precautions—such as glove use—was the primary factor in preventing transmission. This case underscores the importance of routine infection control measures in reducing the risk of mpox spread in healthcare environments.

A recent study published in the American Journal of Infection Control demonstrates that routine infection control measures can effectively prevent mpox transmission in healthcare settings. The case, which took place in a Kentucky nursing home in 2023, involved a certified nursing assistant (CNA) who worked three shifts while infectious with mpox. The worker, who provided direct care such as feeding and hygiene to multiple residents, potentially exposed 56 individuals. Despite this extensive exposure, no secondary infections were reported.

Health authorities responded swiftly by offering post-exposure prophylaxis (PEP) with the Jynneos vaccine to all residents. Twenty-six residents received vaccination within 10 to 15 days of exposure. However, given that Jynneos is most effective within four days of exposure, researchers concluded that vaccination likely played a minimal role in preventing transmission. Instead, they credit the successful containment of mpox to the CNA’s strict adherence to standard precautions, particularly glove use.

This case provides valuable insight into infection control practices for long-term care facilities. It suggests that mpox transmission risk in healthcare settings may be lower than previously feared, provided that proper safety measures are followed. The findings reinforce the importance of training staff on personal protective equipment (PPE) protocols and maintaining rigorous hygiene standards.

While mpox remains a public health concern, especially for immunocompromised individuals, this case study offers reassurance that standard infection prevention strategies—when properly implemented—can significantly mitigate risks. As healthcare facilities continue to navigate emerging infectious diseases, reinforcing these protocols will be essential in protecting both patients and staff.

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